Role of hypothalamic monoamines in nicotine-induced anorexia in menopausal rats

Lihua Zhang, Michael M. Meguid, Go Miyata, Madhu Varma, Serguei O. Fetissov

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Background. Nicotine reduces body weight by reducing appetite. Estradiol modulates food intake. Menopause or ovariectomy (Ovx) increases food intake and body weight. Nicotine and estradiol individually influence hypothalamic dopamine (DA) and serotonin (5-HT), whose interaction influences food intake and body weight. We investigated whether lower weight gain in menopausal smokers is mediated via changes in hypothalamic DA/5-HT. Methods. Ovx or sham-operated female rats had 2 microdialysis guide cannulas simultaneously implanted in ipsilateral ventromedial nucleus of hypothalamus (VMN) and contralateral lateral hypothalamic area (LHA). Rats were divided into 4 groups and received a continuous subcutaneous infusion of nicotine or saline Ovx and sham. DA and 5-HT in LHA and VMN were measured by in vivo microdialysis. Results. Nicotine infusion decreased food intake and body wright in Ovx and sham groups. Increase in LHA-DA and VMN-5-HT in sham group occurred with nicotine, whereas an increase in VMN-DA in Ovx groups with and without nicotine and VMN-5-HT in Ovx group with nicotine was observed. Conclusions. In the presence of estradiol (ovary intact sham-operated rats), nicotine lowers food intake and body weight via increased LHA-DA and VMN-5-HT. In menopause (Ovx rats), nicotine lowers food intake and body weight only via increased VMN-DA and 5-HT. Data show that lower weight gain is mediated via changes in hypothalamic monoamines, primarily via ventromedial hypothalamus.

本文言語English
ページ(範囲)133-142
ページ数10
ジャーナルSurgery
130
2
DOI
出版ステータスPublished - 2001

ASJC Scopus subject areas

  • 外科

フィンガープリント

「Role of hypothalamic monoamines in nicotine-induced anorexia in menopausal rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル