Role of ET(B) receptors and nitric oxide in adrenal catecholamine secretion in anesthetized dogs

Akio Hosokawa, Takahiro Nagayama, Kimiya Masada, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura, Susumu Satoh

研究成果: Article査読

6 被引用数 (Scopus)

抄録

We examined the effects of sarafotoxin 6c (S6c), an endothelin-B (ET(B)) receptor agonist, on adrenal catecholamine secretion in response to cholinergic stimuli in pentobarbital sodium-anesthetized dogs. Drugs were administered intra-arterially into the adrenal gland through the phrenicoabdominal artery. Infusion of S6c attenuated increases in adrenal catecholamine output induced by splanchnic nerve stimulation. The inhibitory effect of S6c on the catecholamine secretion response was suppressed with a selective ET(B) receptor antagonist N-cis 2,6-dimethylpiperidinocarbonyl-L- γ-methylleucyl-D-1-methoxycarbonyltryptophanyl-D-norleucine (BQ-788), a nitric oxide synthase (NOS) inhibitor N(ω)-nitro-L-arginine methyl ester, and a neuronal NOS inhibitor 7-nitroindazole monosodium salt (7-NINA). Similar results were obtained with the catecholamine secretion response induced by injection of ACh. 7-NINA alone did not affect these catecholamine secretion responses. These results suggest that ET(B) receptors play an inhibitory role in adrenal catecholamine secretion by activating neuronal NOS, whereas neuronal NOS is unlikely to be involved in regulation of adrenal catecholamine secretion in the absence of simultaneous ET(B) receptor stimulation.

本文言語English
ページ(範囲)R1051-R1056
ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
277
4 46-4
DOI
出版ステータスPublished - 1999 10月

ASJC Scopus subject areas

  • 生理学
  • 生理学(医学)

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