Role of α-NADH for microsomal ethanol oxidation

研究成果: Article査読

1 被引用数 (Scopus)

抄録

α-NADH* * Reduced form of α-isomer of nicotinamide adenine dinucleotide (1, 2). was found to serve as electron donor for microsomal ethanol oxidation of rat liver. Almost no ethanol oxidation was observed with β-NADH. The α-NADH-dependent ethanol oxidation was almost completely inhibited by 0.1 mM cyanide or azide and strongly abolished in the presence of formate. α-NADH-dependent ethanol oxidation was increased by 1 mM SKF-525A, an inhibitor of microsomal mixed-function oxidase, to about 200%. These results suggested that hydrogen peroxide generated from α-NADH and molecular oxygen in microsomes might be a prerequisite step in the over-all reaction, eventually leading to the peroxidatic ethanol oxidation by catalase to acetaldehyde.

本文言語English
ページ(範囲)793-798
ページ数6
ジャーナルBiochemical and biophysical research communications
50
3
DOI
出版ステータスPublished - 1973 2 5
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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