Ribosome biogenesis factors working with a nuclear envelope sun domain protein new players in the solar system

Chihiro Horigome, Keiko Mizuta

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

The nucleolus, the most prominent structure observed in the nucleus, is often called a "ribosome factory." Cells spend an enormous fraction of their resources to achieve the mass-production of ribosomes required by rapid growth. On the other hand, ribosome biogenesis is also tightly controlled, and must be coordinated with other cellular processes. Ribosomal proteins and ribosome biogenesis factors are attractive candidates for this link. Recent results suggest that some of them have functions beyond ribosome biogenesis. Here we review recent progress on ribosome biogenesis factors, Ebp2 and Rrs1, in yeast Saccharomyces cerevisiae. In this organism, Ebp2 and Rrs1 are found in the nucleolus and at the nuclear periphery. At the nuclear envelope, these proteins interact with a membrane-spanning SUN domain protein, Mps3, and play roles in telomere clustering and silencing along with the silent information regulator Sir4. We propose that a protein complex consisting Ebp2, Rrs1 and Mps3 is involved in a wide range of activities at the nuclear envelope.

本文言語English
ページ(範囲)22-28
ページ数7
ジャーナルNucleus
3
1
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • 細胞生物学

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