Rhodium-catalyzed phenylthiolation reaction of heteroaromatic compounds using α-(phenylthio)isobutyrophenone

Mieko Arisawa, Fumihiko Toriyama, Masahiko Yamaguchi

研究成果: Article査読

34 被引用数 (Scopus)

抄録

In the presence of catalytic amounts of RhH(PPh3)4 and 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-benzothiazoles, 1,3-benzoxazoles, and benzothiophene reacted with α-(phenylthio) isobutyrophenone giving 2-phenylthio derivatives. Reactive monocyclic heteroaromatics, 1-methyl-1,2,3,4-tetrazole and 2-cyanothiophene were also converted into the 5-phenylthio derivatives. The use of an appropriate phenylthio transfer reagent is crucial for the efficient catalyzed conversion of heteroaromatic C-H bonds into C-S bonds.

本文言語English
ページ(範囲)2344-2347
ページ数4
ジャーナルTetrahedron Letters
52
18
DOI
出版ステータスPublished - 2011 5 4

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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