Reward signal in a recurrent circuit drives appetitive long-term memory formation

Toshiharu Ichinose, Yoshinori Aso, Nobuhiro Yamagata, Ayako Abe, Gerald M. Rubin, Hiromu Tanimoto

研究成果: Article査読

60 被引用数 (Scopus)

抄録

Dopamine signals reward in animal brains. A single presentation of a sugar reward to Drosophila activates distinct subsets of dopamine neurons that independently induce short-and long-term olfactory memories (STM and LTM, respectively). In this study, we show that a recurrent reward circuit underlies the formation and consolidation of LTM. This feedback circuit is composed of a single class of reward-signaling dopamine neurons (PAM-α1) projecting to a restricted region of the mushroom body (MB), and a specific MB output cell type, MBON-α1, whose dendrites arborize that same MB compartment. Both MBON-α1 and PAM-α1 neurons are required during the acquisition and consolidation of appetitive LTM. MBON-α1 additionally mediates the retrieval of LTM, which is dependent on the dopamine receptor signaling in the MB α/β neurons. Our results suggest that a reward signal transforms a nascent memory trace into a stable LTM using a feedback circuit at the cost of memory specificity.

本文言語English
論文番号e10719
ジャーナルeLife
4
NOVEMBER2015
DOI
出版ステータスPublished - 2015 11 17

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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