Revolving Vernier Mechanism Controls Size of Linear Homomultimer

Takeo Uchida, Keita Abe, Yuma Endo, Shosei Ichiseki, Satoru Akita, Shiyun Liu, Sho Aradachi, Masataka Saito, Akihiko Fukuchi, Taiyo Kikkawa, Theo Dammaretz, Ibuki Kawamata, Yuki Suzuki, Shin ichiro M. Nomura, Satoshi Murata

研究成果: Article査読

4 被引用数 (Scopus)

抄録

A new kind of the Vernier mechanism that is able to control the size of linear assembly of DNA origami nanostructures is proposed. The mechanism is realized by mechanical design of DNA origami, which consists of a hollow cylinder and a rotatable shaft in it connected through the same scaffold. This nanostructure stacks with each other by the shape complementarity at its top and bottom surfaces of the cylinder, while the number of stacking is limited by twisting angle of the shaft. Experiments have shown that the size distribution of multimeric assembly of the origami depends on the twisting angle of the shaft; the average lengths of the multimer are decamer, hexamer, and tetramer for 0°, 10°, and 20° twist, respectively. In summary, it is possible to affect the number of polymerization by adjusting the precise shape and movability of a molecular structure.

本文言語English
論文番号1702158
ジャーナルSmall
13
41
DOI
出版ステータスPublished - 2017 11月 6

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生体材料
  • 化学 (全般)
  • 材料科学(全般)
  • 工学(その他)

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