TY - JOUR
T1 - Revisiting the Glires concept - Phylogenetic analysis of nuclear sequences
AU - Misawa, Kazuharu
AU - Janke, Axel
N1 - Funding Information:
We thank Masatoshi Nei, Helen Piontkivska, Nikolas Nikolaidis, Yoshi Suzuki, Takeshi Itoh, Galina Glazko, Jongmin Nam, Li Hao, Maria Nilsson, Ulfur Arnason, and two anonymous reviewers for their useful suggestions and comments on the manuscript. This study was supported by a research grant from the National Institutes of Health to Masatoshi Nei (GM20293) and Erik Philip-Sörensen foundation to Axel Janke.
PY - 2003/8
Y1 - 2003/8
N2 - The so-called Glires hypothesis postulates a sister-group relationship between Rodentia (e.g., rat and mouse) and Lagomorpha (e.g., rabbit). Recent molecular phylogenetic analyses have yielded incongruent results, and either supported or refuted the Glires grouping. In order to study this inconsistency we have reconstructed phylogenetic trees based on data sets of 20 orthologous nuclear protein coding genes (6441 aa, sites) and 12 mitochondrial protein coding genes (3559 aa sites). The size of the nuclear data set is considerably larger than any comparable data set hitherto used to study the Glires concept. Analysis of the nuclear data strongly supported the phylogenetic tree (frog, chicken, ((rat, mouse), (rabbit, (human, (cattle, dog))))), while the mt data could not conclusively resolve the position of rabbit relative to that of human. This result was supported by all methods. Thus, the Glires hypothesis was rejected by this study.
AB - The so-called Glires hypothesis postulates a sister-group relationship between Rodentia (e.g., rat and mouse) and Lagomorpha (e.g., rabbit). Recent molecular phylogenetic analyses have yielded incongruent results, and either supported or refuted the Glires grouping. In order to study this inconsistency we have reconstructed phylogenetic trees based on data sets of 20 orthologous nuclear protein coding genes (6441 aa, sites) and 12 mitochondrial protein coding genes (3559 aa sites). The size of the nuclear data set is considerably larger than any comparable data set hitherto used to study the Glires concept. Analysis of the nuclear data strongly supported the phylogenetic tree (frog, chicken, ((rat, mouse), (rabbit, (human, (cattle, dog))))), while the mt data could not conclusively resolve the position of rabbit relative to that of human. This result was supported by all methods. Thus, the Glires hypothesis was rejected by this study.
KW - Divergence times
KW - Eutherian phylogeny
KW - Glires
KW - Nuclear proteins
UR - http://www.scopus.com/inward/record.url?scp=0141832717&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141832717&partnerID=8YFLogxK
U2 - 10.1016/S1055-7903(03)00079-4
DO - 10.1016/S1055-7903(03)00079-4
M3 - Article
C2 - 12878468
AN - SCOPUS:0141832717
VL - 28
SP - 320
EP - 327
JO - Molecular Phylogenetics and Evolution
JF - Molecular Phylogenetics and Evolution
SN - 1055-7903
IS - 2
ER -