Reversion from methionine addiction to methionine independence results in loss of tumorigenic potential of highly-malignant lung-cancer cells

Jun Yamamoto, Yusuke Aoki, Qinghong Han, Norihiko Sugisawa, Yu Sun, Kazuyuki Hamada, Hiroto Nishino, Sachiko Inubushi, Kentaro Miyake, Ryusei Matsuyama, Michael Bouvet, Itaru Endo, Robert M. Hoffman

研究成果: Article査読

抄録

Background/Aim: Methionine addiction, a fundamental and general hallmark of cancer, is due to the excess use of methionine for transmethylation, and is described as the Hoffman-effect. Methionine-addicted cancer cells can revert at low frequency to methionine independence when selected under methionine-restriction. We report here that highly-malignant methionine-addicted H460 human lungcancer cells, when selected for methionine independence, have greatly-reduced tumorigenic potential. Materials and Methods: Methionine-addicted H460 parental cancer cells and methionine-independent revertant H460-R1 cells were injected in nude mice subcutaneously. Results: When the parental H460 methionine-addicted cells were injected in nude mice at 2.5×105, 1×105and 5×104, the cells could form tumors. In contrast, the H460-R1 methionine-independent revertant cells could not form tumors when the above-listed cell numbers were injected in nude mice. Conclusion: There is a tight linkage between methionine addiction and malignancy.

本文言語English
ページ(範囲)641-643
ページ数3
ジャーナルAnticancer research
41
2
DOI
出版ステータスPublished - 2021 2
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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