Reversible Gel–Sol Transition of a Photo-Responsive DNA Gel

Daisuke Kandatsu, Keitel Cervantes-Salguero, Ibuki Kawamata, Shogo Hamada, Shin ichiro M. Nomura, Kenzo Fujimoto, Satoshi Murata

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Stimuli-responsive DNA gels that can undergo a sol-gel transition in response to photo-irradiation provide a way to engineer functional gel material with fully designed DNA base sequences. We propose an X-shaped DNA motif that turns into a gel by hybridization of self-complementary sticky ends. By embedding a photo-crosslinking artificial base in the sticky-end sequence, repetitive gel–sol transitions are achieved through UV irradiation at different wavelengths. The concentration of the DNA motif necessary for gelation is as low as 40 μm after modification of the geometrical properties of the motif. The physical properties, such as swelling degree and diffusion coefficient, were assessed experimentally.

本文言語English
ページ(範囲)1118-1121
ページ数4
ジャーナルChemBioChem
DOI
出版ステータスPublished - 2016 6 16

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 有機化学

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