TY - JOUR
T1 - Retinoid signaling in pathological remodeling related to cardiovascular disease
AU - Kotake, Daisuke
AU - Sato, Taiki
AU - Hirasawa, Noriyasu
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/4/15
Y1 - 2014/4/15
N2 - Retinoids, the active derivatives of vitamin A, are critical signaling molecules in crucial biological processes such as embryonic development, the maintenance of immune function, and cellular differentiation and proliferation. Preclinical studies have shown that retinoids also regulate morphological changes during the progression of cardiovascular disease (CVD). CVD is complexly formed in a mutual chain reaction of various modern lifestyle-related risk factors such as dyslipidemia, hypertension, diabetes, and obesity. These factors induce the pathological remodeling of adipose tissue, the vasculature, and the ventricles, which are a potential target for retinoid signaling. This perspective highlights emerging topics and future prospectives on the relationship between CVD and retinoid signaling.
AB - Retinoids, the active derivatives of vitamin A, are critical signaling molecules in crucial biological processes such as embryonic development, the maintenance of immune function, and cellular differentiation and proliferation. Preclinical studies have shown that retinoids also regulate morphological changes during the progression of cardiovascular disease (CVD). CVD is complexly formed in a mutual chain reaction of various modern lifestyle-related risk factors such as dyslipidemia, hypertension, diabetes, and obesity. These factors induce the pathological remodeling of adipose tissue, the vasculature, and the ventricles, which are a potential target for retinoid signaling. This perspective highlights emerging topics and future prospectives on the relationship between CVD and retinoid signaling.
KW - Cardiovascular disease
KW - RAR
KW - RXR
KW - Remodeling
KW - Retinoid
UR - http://www.scopus.com/inward/record.url?scp=84898056655&partnerID=8YFLogxK
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U2 - 10.1016/j.ejphar.2013.09.021
DO - 10.1016/j.ejphar.2013.09.021
M3 - Article
C2 - 24056119
AN - SCOPUS:84898056655
VL - 729
SP - 144
EP - 147
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -