Retinoic Acid Treatment Induces Cell Death and the Protein Expression of Retinoic Acid Receptor β in the Mesenchymal Cells of Mouse Facial Primordia in Vitro RA/facial mesenchymal cells/chondrogenesis/cell death/RAR b and g protein expression/ micromass culture

Jun Motoyama, Keiko Taki, Noriko Osumi‐Yamashita, Kazuhiro Eto

研究成果: Article査読

4 被引用数 (Scopus)

抄録

We isolated mesenchymal cells from individual facial primordia of mouse embryos on 11 days post coitum and examined the effects of retinoic acid (RA) on chondrogenesis, induction of cell death, and the protein expression of retinoic acid receptor (RAR) β and γ in micromass culture. Under the control condition, cells of both medial and lateral nasal prominences (MNP and LNP) displayed high chondrogenic potential, while those of maxillary and mandibular prominences (Mx and Md) had constant growth activity and low chondrogenic potential. Though none of the cells expressed detectable levels of the RAR β protein, RAR γ was expressed in the cells of all the facial primordia. One μM RA inhibited the chondrogenesis, and induced cell death accompanied with the induction of the RAR β protein in LNP, MX and Md cells within 6 hr. On the contrary, both cell death and RAR β protein induction were detected in the MNP cells treated with RA for 24 hr. These results suggest that the RAR β is involved in the process of the cell death induced by the RA treatment in the mesenchymal cells of the mouse facial primordia.

本文言語English
ページ(範囲)281-288
ページ数8
ジャーナルDevelopment, Growth & Differentiation
36
3
DOI
出版ステータスPublished - 1994 6
外部発表はい

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

フィンガープリント 「Retinoic Acid Treatment Induces Cell Death and the Protein Expression of Retinoic Acid Receptor β in the Mesenchymal Cells of Mouse Facial Primordia in Vitro RA/facial mesenchymal cells/chondrogenesis/cell death/RAR b and g protein expression/ micromass culture」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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