Retinoic acid receptor and retinoid X receptor in ductal carcinoma in situ and intraductal proliferative lesions of the human breast

Naohiro Ariga, Takuya Moriya, Takashi Suzuki, Michio Kimura, Noriaki Ohuchi, Hironobu Sasano

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Retinoic acid (RAR) and retinoid X receptors (RXR) are essential in the transcriptional actions of retinoids. To date, RAR and RXR have not been examined in precancerous lesions and/or ductal carcinoma in situ (DCIS) in human breast. Therefore, we examined RAR and RXR subtypes in DCIS (58 cases), atypical ductal hyperplasia (ADH) (32 cases), and proliferative disease without atypia (PDWA) (32 cases) to study the status of these RARs and RXRs. Immunoreactivities for RAR α, RXR α, RXR β, and RXR γ were all detected in the nuclei of normal ductal epithelia. Immunoreactivity for RAR β was detected exclusively in the nuclei of myoepithelial cells, but not in normal ductal epithelia. Immunoreactivity for RAR γ was not detected in any of the breast tissues examined except for a few cases of PDWA and ADH, and 11 cases of DCIS. The RXR α labeling index (LI) was significantly higher in both DCIS (mean 77.9) and ADH (mean 77.7) than in PDWA (mean 62.8) (P<0.001). RXR β LI was significantly lower in DCIS (mean 81.5) than in both ADH (mean 91.1) and PDWA (mean 91.9) (P=0.0001). Immunoreactivity for RAR α, RXR α, RXR β and RXR γ was widely distributed compared to that of RAR β and RAR γ in DCIS, ADH and PDWA. RAR α LI was significantly correlated with Ki67 LI in DCIS (P=0.0040), especially in estrogen receptor (ER)-positive DCIS. Our results suggest that RXRs are much more widely distributed than RARs in intraductal proliferative lesions of the human breast, but ER-positive DCIS cases with high cell proliferative activity are associated with RAR α, suggesting the possible involvement of retinoids through RAR α in tumor cell proliferation in DCIS.

本文言語English
ページ(範囲)1169-1176
ページ数8
ジャーナルJapanese Journal of Cancer Research
91
11
DOI
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

フィンガープリント

「Retinoic acid receptor and retinoid X receptor in ductal carcinoma in situ and intraductal proliferative lesions of the human breast」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル