Restenosis after percutaneous transluminal coronary angioplasty: Pathologic observations in 20 patients

Masakiyo Nobuyoshi, Takeshi Kimura, Hiroto Ohishi, Hisanori Horiuchi, Hideyuki Nosaka, Naoya Hamasaki, Hiroatsu Yokoi, Koutaku Kim

研究成果: Article査読

341 被引用数 (Scopus)


Histopathologic examination was performed in 20 patients undergoing antemortem coronary angioplasty. Thirty-four lesions were dilated and the interval between coronary angioplasty and death ranged from several hours to 4 years. Intimai proliferation of smooth muscle cells, as a major cause of restenosis, was observed in 83% to 100% of 28 lesions examined 11 days to 2 years after coronary angioplasty. In 20 lesions examined within 6 months, proliferating smooth muscle cells were predominantly of the synthetic type and there was abundant extracellular matrix substance chiefly composed of proteoglycans. In eight lesions examined between 6 months and 2 years, contractile type smooth muscle cells were dominant and extracellular matrix was composed chiefly of collagen. In three lesions examined after 2 years, evidence of antemortem coronary angioplasty was hardly identifiable and these lesions were almost indistinguishable from conventional atherosclerotic plaque. These temporal changes in histologic pattern provide a pathologic background for clinical reports that restenosis is predominantly found within 6 months after coronary angioplasty. Morphometry analysis revealed that the extent of intimai proliferation was significantly greater in lesions with evidence of medial or adventitial tears than in lesions with no or only intimai tears.

ジャーナルJournal of the American College of Cardiology
出版ステータスPublished - 1991

ASJC Scopus subject areas

  • 循環器および心血管医学


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