Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer

Nobuya Katagiri, Takuya Shiraishi, Hiroshi Sato, Akemi Toyota, Chikara Kaneko, Keisuke Yusa, Tomoko Oh-hara, Takashi Tsuruo

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Two enantiomers of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA) which showed a potent and selective anti-HIV effects have been synthesized and evaluated against human immuno-deficiency virus type 1. The result demonstrated that the potent-HIV activity of racemic BCA is expressed solely by the (-) isomer.

本文言語English
ページ(範囲)154-159
ページ数6
ジャーナルBiochemical and biophysical research communications
184
1
DOI
出版ステータスPublished - 1992 4 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント 「Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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