Repression of cell cycle progression by antisense HMG2 RNA

Fuminori Yamazaki, Yasuko Nagatsuka, Hitoshi Shirakawa, Michiteru Yoshida

研究成果: Article査読

25 被引用数 (Scopus)

抄録

The expression level of the HMG2 gene during the cell cycle of rat fibroblast cell lines was analyzed. Northern analysis demonstrated that the level of HMG2 mRNA was markedly enhanced in the post-S phase and reached a maximum at G2 phase, suggesting that expression of the HMG2 gene is not coupled with DNA synthesis. Progression of the cell cycle of COS-1 cells was repressed during G1 to S phase by expression of the antisense RNA for HMG2, resulting in a decrease of cell growth. These results suggest that the fluctuation of the HMG2 message during the cell cycle is not a consequence of but a prerequisite for cell proliferation.

本文言語English
ページ(範囲)1045-1051
ページ数7
ジャーナルBiochemical and biophysical research communications
210
3
DOI
出版ステータスPublished - 1995 5 25
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Repression of cell cycle progression by antisense HMG2 RNA」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル