Replacement of the left-side valves of an implanted total artificial heart

Keiji Kamohara, Stephan Weber, Ryan S. Klatte, Yoshio Ootaki, Masatoshi Akiyama, Michael W. Kopcak, Viviane Luangphakdy, Christine R. Flick, Ji Feng Chen, Jose L. Navia, William A. Smith, Kiyotaka Fukamachi

研究成果: Article査読

2 被引用数 (Scopus)


The MagScrew total artificial heart (TAH) is under development. Despite its anticipated durability and reliability, the possibility of a bioprosthetic valve malfunction exists. As a result, the potential for valve replacement surgery, instead of device replacement, would be desirable after a TAH implant. In two of our 90-day animal experiments, we successfully replaced the left-side valves through a left thoracotomy opposite to the right-sided incision site for the initial TAH implant. The results of these cases suggest that the left-side valves could also be replaced through a left thoracotomy approach in humans. To confirm the ability to access the left-side valves in humans, four human cadaver studies were performed with the use of a mock pump designed for human application. This report describes the operative techniques for left-side valve replacement in animals and discusses the advantages of a left thoracotomy in clinical situations, based on results from the human cadaver studies.

ジャーナルASAIO Journal
出版ステータスPublished - 2006 7

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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