Remnant lipoprotein particles are taken up into myocardium through VLDL receptor - A possible mechanism for cardiac fatty acid metabolism

Akihisa Kamataki, Sadao Takahashi, Katsuhiko Masamura, Tadao Iwasaki, Hiroaki Hattori, Hironobu Naiki, Kazuya Yamada, Jinya Suzuki, Isamu Miyamori, Juro Sakai, Takahiro Fujino, Tokuo T. Yamamoto

研究成果: Article査読

19 被引用数 (Scopus)

抄録

The VLDL (very low-density lipoprotein) receptor is a peripheral lipoprotein receptor expressing in fatty acid active tissues abundantly. In the Balb/c fasting mice VLDL receptor as well as LPL (lipoprotein lipase) FAT (fatty acid translocase)/CD36 H-FABP (heart-type fatty acid-binding protein) ACS (acyl-CoA synthetase) and LCAD (long-chain acyl-CoA dehydrogenase) expressions increased. An electron microscopic examination indicated the lipid droplets that accumulated in the hearts of fasting Balb/c mice. During the development of SD (Sprague-Dawley) rats VLDL receptor LPL FAT/CD36 H-FABP ACS and LCAD mRNAs concomitantly increased with growth. However PK (pyruvate kinase) mRNA expression was negligible. In cultured neonatal rat cardiomyocytes VLDL receptor expression increased with days in culture. Oil red-O staining showed that cardiomyocytes after 7 days in culture (when the VLDL receptor protein is present) accumulated β-migrating VLDL. Thereby we showed that the cardiac VLDL receptor pathway for delivery of remnant lipoprotein particles might be part of a cardiac fatty acid metabolism.

本文言語English
ページ(範囲)1007-1013
ページ数7
ジャーナルBiochemical and biophysical research communications
293
3
DOI
出版ステータスPublished - 2002

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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