Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C: Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives

Yuuki Ishihara; Keisuke Miyazaki; Shuji Yamashita; Masahiro Hirama

doi:10.1246/cl.2009.886

Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C: Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives

Yuuki Ishihara, Keisuke Miyazaki, Shuji Yamashita, Masahiro Hirama

理学研究科・化学専攻

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers that exert their toxicities by binding to the voltage-sensitive sodium channels. We report C7/C51 chemoselective derivatization of 51-hydroxyCTX3C applicable for synthesis of biological probes.

本文言語	English
ページ（範囲）	886-887
ページ数	2
ジャーナル	Chemistry Letters
巻	38
号	9
DOI	https://doi.org/10.1246/cl.2009.886
出版ステータス	Published - 2009 8 10

ASJC Scopus subject areas

化学 (全般)

文献へのアクセス

10.1246/cl.2009.886

他のファイルとリンク

フィンガープリント

「Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C: Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{c8ad44de18ce426385988882843806b8,

title = "Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C: Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives",

abstract = "Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers that exert their toxicities by binding to the voltage-sensitive sodium channels. We report C7/C51 chemoselective derivatization of 51-hydroxyCTX3C applicable for synthesis of biological probes.",

author = "Yuuki Ishihara and Keisuke Miyazaki and Shuji Yamashita and Masahiro Hirama",

year = "2009",

month = aug,

day = "10",

doi = "10.1246/cl.2009.886",

language = "English",

volume = "38",

pages = "886--887",

journal = "Chemistry Letters",

issn = "0366-7022",

publisher = "Chemical Society of Japan",

number = "9",

}

TY - JOUR

T1 - Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C

T2 - Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives

AU - Ishihara, Yuuki

AU - Miyazaki, Keisuke

AU - Yamashita, Shuji

AU - Hirama, Masahiro

PY - 2009/8/10

Y1 - 2009/8/10

N2 - Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers that exert their toxicities by binding to the voltage-sensitive sodium channels. We report C7/C51 chemoselective derivatization of 51-hydroxyCTX3C applicable for synthesis of biological probes.

AB - Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers that exert their toxicities by binding to the voltage-sensitive sodium channels. We report C7/C51 chemoselective derivatization of 51-hydroxyCTX3C applicable for synthesis of biological probes.

UR - http://www.scopus.com/inward/record.url?scp=68149099573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68149099573&partnerID=8YFLogxK

U2 - 10.1246/cl.2009.886

DO - 10.1246/cl.2009.886

M3 - Article

AN - SCOPUS:68149099573

VL - 38

SP - 886

EP - 887

JO - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

IS - 9

ER -