Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C: Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives

Yuuki Ishihara; Keisuke Miyazaki; Shuji Yamashita; Masahiro Hirama

doi:10.1246/cl.2009.886

Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C: Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives

Yuuki Ishihara, Keisuke Miyazaki, Shuji Yamashita, Masahiro Hirama

理学研究科・化学専攻

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers that exert their toxicities by binding to the voltage-sensitive sodium channels. We report C7/C51 chemoselective derivatization of 51-hydroxyCTX3C applicable for synthesis of biological probes.

本文言語	English
ページ（範囲）	886-887
ページ数	2
ジャーナル	Chemistry Letters
巻	38
号	9
DOI	https://doi.org/10.1246/cl.2009.886
出版ステータス	Published - 2009 8 10

ASJC Scopus subject areas

Chemistry(all)

文献へのアクセス

10.1246/cl.2009.886

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引用スタイル

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AU - Yamashita, Shuji

AU - Hirama, Masahiro

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