Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C: Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives

Yuuki Ishihara, Keisuke Miyazaki, Shuji Yamashita, Masahiro Hirama

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers that exert their toxicities by binding to the voltage-sensitive sodium channels. We report C7/C51 chemoselective derivatization of 51-hydroxyCTX3C applicable for synthesis of biological probes.

本文言語English
ページ(範囲)886-887
ページ数2
ジャーナルChemistry Letters
38
9
DOI
出版ステータスPublished - 2009 8 10

ASJC Scopus subject areas

  • 化学 (全般)

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