Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer

Yoshitaka Kinouchi, Nobuo Hiwatashi, Seiichi Higashioka, Fumio Nagashima, Masaki Chida, Takayoshi Toyota

研究成果: Article査読

27 被引用数 (Scopus)

抄録

The insulin-like growth factor II gene (IGF2) is imprinted in normal human tissues, and relaxation of imprinting (ROI) of IGF2 is thought to play an important role in human childhood tumors. Taking advantage of an Apa I polymorphism in this gene, allelic expression of IGF2 has now been examined in colorectal cancer. Thirteen of 33 patients studied were informative. Colorectal cancer tissue from 5 of the 13 informative patients exhibited ROI of IGF2; furthermore, normal mucosa from 3 of these 5 patients also showed weak biallelic expression of IGF2. ROI of IGF2 may thus also play a role in colorectal cancer.

本文言語English
ページ(範囲)105-108
ページ数4
ジャーナルCancer Letters
107
1
DOI
出版ステータスPublished - 1996 10 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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