TY - JOUR
T1 - Relationship between Viscosity and Acyl Tail Dynamics in Lipid Bilayers
AU - Nagao, Michihiro
AU - Kelley, Elizabeth G.
AU - Faraone, Antonio
AU - Saito, Makina
AU - Yoda, Yoshitaka
AU - Kurokuzu, Masayuki
AU - Takata, Shinichi
AU - Seto, Makoto
AU - Butler, Paul D.
N1 - Funding Information:
Access to the NGA-NSE Instrument was provided by the Center for High Resolution Neutron Scattering, a partnership between the National Institute of Standards and Technology and the National Science Foundation under Agreement No. DMR-2010792. The synchrotron radiation experiments were performed at the BL09XU of SPring-8 with the approval of the Japan Synchrotron Radiation Research Institute (JASRI) (Proposal No. 2017B1512 and 2018B1491). This work was partially supported by JSPS KAKENHI (Grant-in-Aid for Young Scientists) Grant No. 19K20600 and JST, CREST Grant No. JPMJCR2095, Japan.
Publisher Copyright:
© 2021 American Physical Society.
PY - 2021/8/13
Y1 - 2021/8/13
N2 - Membrane viscosity is a fundamental property that controls molecular transport and structural rearrangements in lipid membranes. Given its importance in many cell processes, various experimental and computational methods have been developed to measure the membrane viscosity, yet the estimated values depend highly on the method and vary by orders of magnitude. Here we investigate the molecular origins of membrane viscosity by measuring the nanoscale dynamics of the lipid acyl tails using x-ray and neutron spectroscopy techniques. The results show that the membrane viscosity can be estimated from the structural relaxation times of the lipid tails.
AB - Membrane viscosity is a fundamental property that controls molecular transport and structural rearrangements in lipid membranes. Given its importance in many cell processes, various experimental and computational methods have been developed to measure the membrane viscosity, yet the estimated values depend highly on the method and vary by orders of magnitude. Here we investigate the molecular origins of membrane viscosity by measuring the nanoscale dynamics of the lipid acyl tails using x-ray and neutron spectroscopy techniques. The results show that the membrane viscosity can be estimated from the structural relaxation times of the lipid tails.
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U2 - 10.1103/PhysRevLett.127.078102
DO - 10.1103/PhysRevLett.127.078102
M3 - Article
C2 - 34459628
AN - SCOPUS:85113142803
VL - 127
JO - Physical Review Letters
JF - Physical Review Letters
SN - 0031-9007
IS - 7
M1 - 078102
ER -