Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications

T. Hishinuma, H. Tsukamoto, K. Suzuki, M. Mizugaki

研究成果: Article査読

36 被引用数 (Scopus)

抄録

To elucidate the relationship between the thromboxane A2/prostacyclin (TXA2/PGI2) ratio and diabetic complications, the levels of 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-prostaglandin F, the urinary metabolites of thromboxane A2 and prostacyclin, were measured in diabetics by gas chromatography/selected ion monitoring. We compared the TXA2/PGI2 ratio in healthy volunteers and diabetics. The TXA2/PGI2 ratio of diabetics was significantly higher than that of healthy volunteers and we could reconfirm the hypercoagulable condition in diabetics. We also investigated the difference of TXA2/PGI2 levels in diabetics with retinopathy and neuropathy. The TXA2/PGI2 ratio of diabetics with retinopathy showed significantly higher level than without retinopathy. However, the TXA2/PGI2 ratio of diabetics with neuropathy was the same as without neuropathy. These results suggest that the TXA2/PGI2 ratio reflects the pathological conditions of diabetes, especially the change of vasculature. The monitoring and improvement of TXA2/PGI2 ratio could be useful for the prevention of diabetic vascular complications.

本文言語English
ページ(範囲)191-196
ページ数6
ジャーナルProstaglandins Leukotrienes and Essential Fatty Acids
65
4
DOI
出版ステータスPublished - 2001

ASJC Scopus subject areas

  • 臨床生化学
  • 細胞生物学

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