Purpose: The purpose of this study was to investigate the relationship between laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) measurements of ocular microcirculation in normal and open-angle glaucoma (OAG) subjects. Methods: This study included 18 eyes of 18 OAG patients and ten eyes of ten age-matched healthy controls. LSFG was used to measure mean blur rate (MBR) in the optic nerve head (ONH) vessel area (MV) and tissue area (MT). OCTA was used to measure a new parameter, peripapillary relative intensity (PRI), in the superficial retina, superficial choroid, and deep choroid. Statistical associations were then determined. Results: MV, MT, superficial-retinal PRI, and superficial-choroidal PRI were lower in the OAG subjects than the controls (P = 0.02, P < 0.001, P = 0.02 and P = 0.008, respectively). Superficial-retinal PRI was correlated with MV and MT (R = 0.68, P < 0.001 and R = 0.63, P < 0.001, respectively). Superficial-choroidal PRI was also correlated with MV and MT (R = 0.45, P = 0.02 and R = 0.57, P = 0.002, respectively). Multiple regression analysis revealed that MV and MT independently contributed to superficial-retinal PRI (P = 0.008 and P = 0.04, respectively), while only MT contributed to superficial-choroidal PRI (P = 0.03). Conclusions: Our finding that OCTA-measured PRI was related to LSFG-measured MBR was reasonable, considering the vascular anatomy of the eye. Thus, PRI, like MBR, may be a promising biomarker of ocular microcirculation that can reveal the presence of ocular diseases such as OAG.
|ジャーナル||Graefe's Archive for Clinical and Experimental Ophthalmology|
|出版ステータス||Published - 2017 8 1|
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience