Regulatory mechanisms of cellular response to oxidative stress

Ken Itoh, Tetsuro Ishii, Nobunao Wakabayashi, Masayuki Yamamoto

研究成果: Article査読

274 被引用数 (Scopus)

抄録

An antioxidant responsive element (ARE) or electrophile responsive element (EpRE) mediates the transcriptional activation of genes encoding phase II drug metabolizing enzymes. The ARE consensus sequence shows high similarity to an erythroid gene regulatory element, and based on the observation, we have recently found that transcription factor Nrf2 is essential for the coordinate induction of phase II detoxifying enzymes. The expression of anti-oxidative stress enzyme genes is also regulated by Nrf2. Detailed analysis of the regulatory mechanisms of Nrf2 activity has ultimately led us to the identification of a new protein, which we have named Keap1, that suppresses Nrf2 activity by specific binding to its evolutionarily-conserved N-terminal Neh2 regulatory domain.

本文言語English
ページ(範囲)319-324
ページ数6
ジャーナルFree Radical Research
31
4
DOI
出版ステータスPublished - 1999 10 6
外部発表はい

ASJC Scopus subject areas

  • Biochemistry

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