Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha

Keisuke Tachibana, Naohiko Anzai, Chihiro Ueda, Tatsuya Katayama, Daisuke Yamasaki, Takayoshi Kirino, Rika Takahashi, Kenji Ishimoto, Hidenori Komori, Toshiya Tanaka, Takao Hamakubo, Yukihiko Ueda, Hiroyuki Arai, Juro Sakai, Tatsuhiko Kodama, Takefumi Doi

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Although PDZK1 is a well-known adaptor protein, the mechanisms for its role in transcriptional regulation are largely unknown. The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor that plays an important role in the regulation of lipid homeostasis. Previously, we established a tetracycline-regulated human cell line that can be induced to express PPARα and identified candidate target genes, one of which was PDZK1. In this study, we cloned and characterized the promoter region of the human pdzk1 gene and determined the PPAR response element. Finally, we demonstrate that endogenous PPARα regulates PDZK1 expression.

本文言語English
ページ(範囲)3884-3888
ページ数5
ジャーナルFEBS Letters
582
28
DOI
出版ステータスPublished - 2008 11 26
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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