[Regulation of osteoclast development by immunoglobulin-like receptors].

Masanori Inui, Toshiyuki Takai

研究成果: Review article査読

抄録

Immunoglobulin-like receptors (IgLR) , expressed in a wide range of cells in immune system, provide a positive and negative regulation of immune responses. Activation signals initiated by activating IgLR associating with ITAM-containing adapter proteins DAP12 and FcRγ are indispensable for the development of osteoclasts. On the other hand, ITIM signals induced by inhibitory IgLR regulate osteoclast development and activation. Thus, ITAM and ITIM play important roles in the maintenance of bone homeostasis.

本文言語English
ページ(範囲)1651-1657
ページ数7
ジャーナルClinical calcium
22
11
出版ステータスPublished - 2012 11

ASJC Scopus subject areas

  • 医学(全般)

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