Regulation of insulin gene transcription

Kinuko Ohneda, Hooi Ee, Michael German

研究成果: Article査読

105 被引用数 (Scopus)

抄録

Recent studies of the insulin gene promoter and the transcription factors that regulate it have expanded our understanding of both how the production of insulin is restricted to the pancreatic β-cell, and how that production is regulated by physiologic signals such as glucose. A picture is emerging in which an elaborate set of transcription factors binds to specific sequences along the promoter and recruits additional transcriptional co-activators to build a functional transcriptional activation complex that is unique to β-cells. Surprisingly, however, genetic experiments in mice have demonstrated an unexpected degree of redundancy in the factors that control insulin gene expression, and have revealed the presence of a network of transcription factors that coordinate the expression of factors forming the insulin gene activation complex.

本文言語English
ページ(範囲)227-233
ページ数7
ジャーナルSeminars in Cell and Developmental Biology
11
4
DOI
出版ステータスPublished - 2000
外部発表はい

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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