Regulation of germ cell death in mammalian gonads

研究成果: Article査読

38 被引用数 (Scopus)

抄録

A large number of primordial germ cells (PGCs), as well as spermatogonia, undergo programmed cell death or apoptosis in the physiological context. In this process, environmental, cytoplasmic and nuclear factors are involved. Bcl-2 and its related molecules are known as general regulators of cell death, and some are important for survival of PGCs and spermatogonia. Steel factor, a ligand for c-Kit, also supports growth and survival of these cells. In addition, bone morphogenetic protein (BMP)8B and Desert Hedgehog (Dhh), which are secreted proteins, and a nuclear factor, c- Myc, play a role in spermatocyte survival. This suggests that germ cell survival or death at each stage of differentiation is precisely controlled by specific signalling pathways which consist of a number of molecules.

本文言語English
ページ(範囲)142-148
ページ数7
ジャーナルAPMIS
106
1
DOI
出版ステータスPublished - 1998 1 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

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