Regional coupling of blood flow and methionine uptake in an experimental tumor assessed with autoradiography

Yoshinao Abe, Taiju Matsuzawa, Masatoshi Itoh, Kiichi Ishiwata, Takehiko Fujiwara, Tachio Sato, Keiichiro Yamaguchi, Tatsuo Ido

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Regional distribution of L-[methyl-14C] methionine (14C-MET) and 4-[18F] fluoro-antipyrine was compared using experimental rat tumors (AH109A) and a computerized autoradiogram image processor. Tissue distributions of the two tracers were found to be inhomogeneous in the tumor with nearly identical image patterns. Analysis of tissue radioactivities revealed that 82% of 14C-MET was derived from the acid insoluble fraction at 60 min after injection. The present study showed that 14C-MET uptake closely relates to tissue blood flow and may depend on its blood to tissue transport. Rapid incorporation of MET in the acid insoluble fraction implies that it is rapidly metabolized after transport into tumor tissue.

本文言語English
ページ(範囲)388-392
ページ数5
ジャーナルEuropean Journal of Nuclear Medicine
14
7-8
DOI
出版ステータスPublished - 1988 9月

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング

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