Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: A comparative study using positron emission tomography

Toru Imamura, Kazunari Ishii, Masahiro Sasaki, Hajime Kitagaki, Shigeru Yamaji, Nobutsugu Hirono, Tatsuo Shimomura, Mamoru Hashimoto, Satoshi Tanimukai, Hiroaki Kazui, Etsuro Mori

研究成果: Article査読

119 被引用数 (Scopus)

抄録

Regional cerebral metabolic rate of glucose (rCMRglc) was studied in 19 patients with a clinical diagnosis of dementia with Lewy bodies (DLB) and 19 patients with a clinical diagnosis of Alzheimer's disease (AD), using [18F]fluorodeoxyglucose ([18F]FDG) and positron emission tomography (PET). The two groups were matched with age, gender, disease duration and severity of cognitive disturbances. In 'dementia with Lewy bodies' (DLB) patients, when compared with AD patients, significant rCMRglc decreases were distributed in the temporo-parieto-occipital association cortices and the cerebellar hemispheres. In contrast; the medial temporal and cingulate rCMRglc were significantly lower in AD patients than those in DLB patients. These different regional emphases of glucose hypometabolism are consistent with the pathological and neurochemical differences between DLB and AD and explain the different clinical features of the two diseases.

本文言語English
ページ(範囲)49-52
ページ数4
ジャーナルNeuroscience Letters
235
1-2
DOI
出版ステータスPublished - 1997 10 10

ASJC Scopus subject areas

  • 神経科学(全般)

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