Reductive glutathione-responsive molecular release using water-soluble poss network polymers

Kazuo Tanaka, Wataru Ohashi, Narufumi Kitamura, Yoshiki Chujo

研究成果: Article査読

28 被引用数 (Scopus)

抄録

We describe in the manuscript reductive glutathione (GSH)-responsive molecular release using polyhedral oligomeric silsesquioxane (POSS) network polymers. A series of the POSS network polymers with the different crosslinking ratios containing disulfide linkers were synthesized, and molecular encapsulation by the polymers was executed. We found that the POSS polymers encapsulated the molecules in aqueous solutions. On the contrary, the reduced polymers hardly retained the guest molecules. By using the change of the encapsulation ability of the polymers via reduction, we demonstrated that the dye-loaded network polymers released the encapsulated molecules. Finally, we were able to detect GSH with intercellular concentration by the increase of the intensity of fluorescence emission.

本文言語English
ページ(範囲)612-616
ページ数5
ジャーナルBulletin of the Chemical Society of Japan
84
6
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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