Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease

Takashi Kuda, Mikio Shoji, Hiroyuki Arai, Seiichi Kawashima, Takaomi C. Saido

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Previously, we hypothesized that aminopeptidase-catalyzed proteolysis may limit the rate of β-amyloid catabolism in brain and that reduction of a certain aminopeptidase activity may lead to deposition of peptidic metabolites represented by β-amyloid and thus to Alzheimer's disease (AD). To explore this possibility in clinical situations and to seek a possible biochemical marker for the disease, we quantitated four classes of aminopeptidase activities in cerebrospinal fluids and heparinized plasma from sporadic AD patients and age-matched controls collected in two independent medical institutions. We found that only plasma glutamyl aminopeptidase activity was significantly and consistently lower in AD patients. Although the mechanism leading to such a biochemical change in plasma remains to be elucidated, the results provide support for the aminopeptidase hypothesis and indicate that the enzyme activity may potentially be used as a diagnostic/predictive marker for AD.

本文言語English
ページ(範囲)526-530
ページ数5
ジャーナルBiochemical and biophysical research communications
231
3
DOI
出版ステータスPublished - 1997 2月 24
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル