Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene

Tomoko Sugawara, Kei Nemoto, Yasuhiro Adachi, Nozomi Yamano, Nobuko Tokuda, Masahiko Muto, Ryuhei Okuyama, Shingo Sakai, Yuji Owada

研究成果: Letter査読

13 被引用数 (Scopus)

抄録

Fatty acid binding proteins (FABPs) are capable of binding long-chain FA and are involved in intracellular FA transport and signal transduction. In sebaceous glands, FABP5 is highly expressed in differentiated sebocytes; though, its function remains unclear. In this study, we examined the role of FABP5 in sebocytes using FABP5-deficient mice. The size of sebaceous glands was significantly reduced, while the sebum volume was increased with altered lipid composition in FABP5-deficient mice. However, no significant differences were discerned in the expression of proliferation or differentiation markers including Blimp1, c-myc, Ki67 and peroxisome proliferator-activated receptors (PPAR)γ between wild-type and FABP5-deficient sebaceous glands. The expression of cellular retinoic acid binding protein-2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5-deficient mice. These results suggest that FABP5 is involved in the regulation of sebaceous gland activity through modulation of cellular lipid signalling and/or metabolism in the sebocytes.

本文言語English
ページ(範囲)543-546
ページ数4
ジャーナルExperimental Dermatology
21
7
DOI
出版ステータスPublished - 2012 7
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 皮膚病学

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