Reduced Cd4+Cd25+ T cells in patients with idiopathic thrombocytopenic purpura

Miho Sakakura, Hideo Wada, Isao Tawara, Tsutomu Nobori, Takashi Sugiyama, Norimasa Sagawa, Hiroshi Shiku

研究成果: Article査読

132 被引用数 (Scopus)

抄録

Immunoregulatory CD4+CD25+ T cells play an important role in the induction and maintenance of peripheral self-tolerance. These professional regulatory cells prevent the activation and proliferation of potentially autoreactive T cells that have escaped thymic deletion. Therefore, CD4+CD25+ T cells are believed to possibly play an important role in pathogenic autoimmune diseases. We measured the count of CD4+CD25+ T cells in 44 patients with idiopathic thrombocytopenic purpura (ITP), and the number of CD4+CD25+ T cells and clinical features were then analyzed. By using a flow cytometric analysis, the number of CD4+CD25+ T cells in the patients with ITP showed a very wide distribution in comparison to healthy volunteers. The number of CD4+CD25+ T cells was significantly lower in the ITP patients in the severe phase, and in patients positive for anti-glycoprotein IIb-IIIa antibody. However, the number of those cells increased in the patients at the complete remission phase, especially after a splenectomy. The Foxp3 mRNA levels of peripheral blood mononuclear cells (PBMC) of ITP patients were higher with an improved platelet count than in those with a low platelet count. In addition, the Foxp3 mRNA levels closely correlated with the number of CD4+CD25+ cells. These mechanisms remain to be fully elucidated, however, the count of CD4+CD25+ T cells is considered to possibly be related to the severity of ITP.

本文言語English
ページ(範囲)187-193
ページ数7
ジャーナルThrombosis Research
120
2
DOI
出版ステータスPublished - 2007
外部発表はい

ASJC Scopus subject areas

  • 血液学

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