TY - JOUR
T1 - Red light-promoted skin barrier recovery
T2 - Spatiotemporal evaluation by transepidermal potential
AU - Abe, Yuina
AU - Konno, Hajime
AU - Yoshida, Shotaro
AU - Yamauchi, Takeshi
AU - Yamasaki, Kenshi
AU - Denda, Mitsuhiro
AU - Nishizawa, Matsuhiko
N1 - Funding Information:
This work was supported by Tohoku University Institute for Promoting Graduate Degree Programs Division for Interdisciplinary Advanced Research and Education (DIARE), Center of Innovation Program (COI-Stream), MIRAI Project (17944087) of Japan Science and Technology Agency (JST), and financially by Grand-in-Aid for JSPS Research Fellow (17J03919), Scientific Research A (18H04158) and Challenging Exploratory Research (18K19896) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. Shiseido Research Center provided support in the form of salaries for an author MD, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of the author are articulated in the "author contributions" section.
Publisher Copyright:
© 2019 Abe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - The light-promoted recovery of epidermal barrier of skin was evaluated by the associated recovery of transepidermal potential (TEP), the potential difference between the surface and dermis of skin, by using porcine skin samples. An accelerated recovery of TEP was observed by irradiation of red light with the irradiance of 40 mW/cm2 and a duration of > 10 min. The influence of the light stimulation to the surroundings (~ 20 mm) was also observed. The irradiations of blue and purple lights were ineffective in accelerating the barrier recovery. These characteristics of the light stimulation would be useful for the design of effective and safe phototherapy devices for skin. The present study proves that the TEP can serve as a spatiotemporal indicator of the epidermal barrier function.
AB - The light-promoted recovery of epidermal barrier of skin was evaluated by the associated recovery of transepidermal potential (TEP), the potential difference between the surface and dermis of skin, by using porcine skin samples. An accelerated recovery of TEP was observed by irradiation of red light with the irradiance of 40 mW/cm2 and a duration of > 10 min. The influence of the light stimulation to the surroundings (~ 20 mm) was also observed. The irradiations of blue and purple lights were ineffective in accelerating the barrier recovery. These characteristics of the light stimulation would be useful for the design of effective and safe phototherapy devices for skin. The present study proves that the TEP can serve as a spatiotemporal indicator of the epidermal barrier function.
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U2 - 10.1371/journal.pone.0219198
DO - 10.1371/journal.pone.0219198
M3 - Article
C2 - 31291308
AN - SCOPUS:85069615216
SN - 1932-6203
VL - 14
JO - PLoS One
JF - PLoS One
IS - 7
M1 - e0219198
ER -