Red blood cell deformation in flows through a PDMS hyperbolic microchannel

T. Yaginuma, M. S.N. Oliveira, R. Lima, T. Ishikawa, T. Yamaguchi

研究成果: Conference contribution

11 被引用数 (Scopus)

抄録

Red blood cell (RBC) deformability is extremely important in the context of microcirculation as RBCs need to flow through thin capillaries in order to deliver oxygen to the human body. Although most studies on RBC deformability consider the effect of shear flow alone, extensionally-dominated flows are often found in the human circulatory system. This study aims to characterize the deformation of RBCs in microfluidic extensional flows. For this purpose, we designed a microchannel having a hyperbolic shaped-contraction, where the cells experience an extensionally-dominated flow near the centerline. The deformation index (DI) of the RBCs travelling along the central region of the channel were measured in two pre-defined regions at two different flow rates. The results demonstrate the highly deformable nature of RBCs under strong extensional flows.

本文言語English
ホスト出版物のタイトルTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
ページ505-507
ページ数3
出版ステータスPublished - 2011 11 23
イベントNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
継続期間: 2011 6 132011 6 16

出版物シリーズ

名前Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
2

Other

OtherNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
国/地域United States
CityBoston, MA
Period11/6/1311/6/16

ASJC Scopus subject areas

  • ハードウェアとアーキテクチャ
  • 電子工学および電気工学

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