Receptors and enzymes for medical sensing of L-glutamate

Ayumi Hirano, Masao Sugawara

研究成果: Review article査読

19 被引用数 (Scopus)

抄録

Medical sensing systems using isolated or intact glutamate receptor (GluR) ion channels and glutamate oxidase (GluOx) are discussed for L-glutamate, one of the principal neurotransmitter in the central nervous systems of mammalian brain, and related agonists. The GluR-based sensing system used for the evaluation of signal transduction ability of GluR channels demonstrate that the agonist selectivity based on the signal transduction ability is not parallel to that of the binding assay. On the other hand, the appropriate design of the enzyme system, namely glutamate oxidase (GluOx), in combination with horseradish peroxidase (HRP), enables to real-time monitoring of L-glutamate in vivo and in vitro and also to visualize its release in submerged, acute mouse hippocampal slices.

本文言語English
ページ(範囲)1091-1100
ページ数10
ジャーナルMini-Reviews in Medicinal Chemistry
6
10
DOI
出版ステータスPublished - 2006 10 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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