Recent patents of TGF-beta family and VEGF associated with ovarian follicular development in mammals.

Takashi Shimizu, Yasuyuki Abe, Takuya Wakai, Yumi Hoshino, Akio Miyamoto, Eimei Sato

    研究成果: Article査読

    3 被引用数 (Scopus)

    抄録

    In mammalian ovary, follicular development in mammals is regulated by the complex process including endocrine, paracrine and autocrine. During the last decade, the role of growth factors in ovarian folliculogenesis has been extensively studied in mammals. In particular, a growing body of evidence indicates that the vascular endothelial growth factor (VEGF) system plays a key role in follicular development and atresia in the woman, rodents and domestic animal species. More recently, the bone morphogenetic protein (BMP) and growth differentiation factor (GDF) that belong to TGF-beta family have been shown to be involved in the regulation of follicle growth. In this paper, we will essentially consider the role of these growth factor systems in mammalian ovary. Moreover, we will review recent patents associated with ovarian follicular development in mammals.

    本文言語English
    ページ(範囲)195-199
    ページ数5
    ジャーナルRecent patents on DNA & gene sequences
    1
    3
    DOI
    出版ステータスPublished - 2007

    ASJC Scopus subject areas

    • Biotechnology
    • Molecular Biology
    • Genetics(clinical)

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