Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging

Michal T. Krauze, Tracy R. McKnight, Yoji Yamashita, John Bringas, Charles O. Noble, Ryuta Saito, Karsten Geletneky, John Forsayeth, Mitchel S. Berger, Pamela Jackson, John W. Park, Krystof S. Bankiewicz

研究成果: Article査読

79 被引用数 (Scopus)

抄録

Liposomes loaded with Gadoteridol, in combination with convection-enhanced delivery (CED), offer an excellent option to monitor CNS delivery of therapeutic compounds with MRI. In previous studies, we investigated possible clinical applications of liposomes to the treatment of brain tumors. In this study, up to 700 μl of Gadoteridol/rhodamine-loaded liposomes were distributed in putamen, corona radiata and brainstem of non-human primates. Distribution was monitored by real-time MRI throughout infusion procedures and allowed accurate calculation of volume of distribution within anatomical structures. We found that different regions of the brain gave various volumes of distribution when infused with the same volume of liposome. Based on these findings, distinct distribution pathways within infused structures can be predicted. This work underlines the importance of monitoring drug delivery to CNS and enables accurate delivery of drug-loaded liposomes to specific brain regions with a standard MRI procedure. Findings presented in this manuscript may allow for modeling of parameters used for direct delivery of therapeutics into various regions of the brain.

本文言語English
ページ(範囲)20-26
ページ数7
ジャーナルBrain Research Protocols
16
1-3
DOI
出版ステータスPublished - 2005 12 1
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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