Rat kidney thromboxane synthase: cDNA cloning and gene expression regulation in hydronephrotic kidney

Eikatsu Tsutsumi, Kazuhisa Takeuchi, Takaaki Abe, Nobuyuki Takahashi, Taro Kato, Yoshihiro Taniyama, Yukio Ikeda, Sadayoshi Ito, Keishi Abe

研究成果: Article査読

7 被引用数 (Scopus)

抄録

We isolated a rat homolog of thromboxane (TX) synthase cDNA (~1.8 kb) from the kidney with a fragment of human TX synthase cDNA amplified by polymerase chain reaction with placenta cDNA as a template. Northern blot analysis has shown that rat TX synthase gene is expressed abundantly in lung, liver, and uterus; moderately in kidney. TX synthase mRNA expression was up- regulated in hydronephrotic kidney made by ureter ligation. In conclusion, we have revealed the structure of rat kidney TX synthase. Up-regulation of renal TX synthase, which may cause stimulation of TX synthesis, is possibly implicated in the tissue injury in hydronephrotic kidney.

本文言語English
ページ(範囲)423-431
ページ数9
ジャーナルProstaglandins
53
6
DOI
出版ステータスPublished - 1997 6

ASJC Scopus subject areas

  • 生化学
  • 内分泌学

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