Ras target protein canoe is a substrate for Cdc2 and Cdk5 kinases

Kuniaki Takahashi, Noriko Hamada, Daisuke Yamamoto

    研究成果: Article査読

    4 被引用数 (Scopus)

    抄録

    Mutations in the canoe locus of Drosophila lead to failure in the dorsal closure of the embryonic epidermis and pattern formation defects in imaginai eyes and wings. In the wing, the canoe mutants develop extra veins when they are heterozygous for shaggy, a mutation in the locus encoding the glycogen synthose kinase 3β; (Gsk3β), which has been known to phosphorylate the Armadillo protein. Although Canoe has a putative target sequence for phosphorylation by Gsk3β similar to that found in Armadillo, in vitro experiments indicate that Canoe is not phosphorylated by Gsk3β. Instead, Canoe is demonstrated to be a good substrate of Cdc2 and Cdk5 kinases. Thus, Cdc2 and Cdk5 kinases are the potential regulators of the function of Canoe in morphogenesis.

    本文言語English
    ページ(範囲)102-107
    ページ数6
    ジャーナルArchives of Insect Biochemistry and Physiology
    49
    2
    DOI
    出版ステータスPublished - 2002 2月 1

    ASJC Scopus subject areas

    • 生理学
    • 生化学
    • 昆虫科学

    フィンガープリント

    「Ras target protein canoe is a substrate for Cdc2 and Cdk5 kinases」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル