Rapid turnover of low density lipoprotein receptor in human monocytic THP-1 cells

Ryoji Hamanaka, Tadashi Seguchi, Yasufumi Sato, Mayumi Ono, Kimitoshi Kohno, Michihiko Kuwano

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We examined whether human monocyte-derived macrophages had low density lipoprotein (LDL) receptors with a short life span. The human monocytic leukemia cell line, THP-1, was highly differentiated when treated with phorbol ester. LDL receptors degraded rapidly with half-lives of 3-4 h in THP-1 cells before phorbol ester treatment. During the transition into monocytic cells, expression of the LDL receptor gene was not affected. However, relative degradation rates of LDL receptors normalized by those of cellular total proteins were about twice as fast in phorbol ester-treated THP-1 cells compared to untreated cells.

本文言語English
ページ(範囲)261-263
ページ数3
ジャーナルFEBS Letters
294
3
DOI
出版ステータスPublished - 1991 12 9
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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