Rapid synthesis of 62Zn-Labeled S-Glycosylated porphyrin as positron emission tomography tracers for in vivo PET imaging

Masato Tamura, Hirofumi Matsui, Shiho Hirohara, Kiyomi Kakiuchi, Masao Tanihara, Naruto Takahashi, Kozi Nakai, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Positron emission tomography (PET) with [18F]-FDG can display cancerous activity depending on glucose uptake. Consequently, different PET tracers with different metabolisms are needed for further indication. We have developed multifunctional PET agents by combining 62Zn2+ ion with laserphyrin- and bisglycosylated 5,10,15,20-tetrakis(pentafluorophenyl) porphyrins (H2Glccis-2 and H2Glctrans-2), which can be easily synthesized and have a half-life of 9h. 62Zn-Labeled chemicals were successfully detected as PET signals in vivo and showed PDT-induced cell death by photoirradiation.

本文言語English
ページ(範囲)778-780
ページ数3
ジャーナルChemistry Letters
43
6
DOI
出版ステータスPublished - 2014
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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