Randomized study of dexamethasone treatment for delayed emesis, anorexia and fatigue induced by irinotecan

Akira Inoue, Yasuhide Yamada, Yasuhiro Matsumura, Yasuhiro Shimada, Kei Muro, Masahiro Gotoh, Tetsuya Hamaguchi, Toshiro Mizuno, Kuniaki Shirao

研究成果: Article査読

37 被引用数 (Scopus)


The prevention of post-chemotherapy symptoms such as delayed emesis, anorexia, and fatigue induced by irinotecan has not been studied. We compared the effects of dexamethasone (Dex) with those of a placebo on these symptoms in a randomized study. Seventy patients scheduled to receive irinotecan chemotherapy were enrolled in the study and randomly divided into a treatment of a placebo group. In the treatment group, 8 mg of Dex were administered on days 2-4 after the start of chemotherapy. All patients in both groups received Dex and granisetron for prophylaxis against acute emesis on day 1. We evaluated 68 patients (35 receiving Dex, 33 receiving the placebo). Although delayed emesis was completely prevented in most of patients in both groups (Dex, 82.9%; placebo, 78.8%), anorexia and fatigue were more completely prevented in those in the Dex group (Dex, 62.9% and 77.1%, placebo, 39.4% and 57.6%, respectively). The effect of Dex on improving simultaneous prophylaxis against all three symptoms was almost significant (Dex, 60.0%; placebo, 36.4%; P=0.058). The safety profiles of the two groups were not discernibly different. These results suggest that treatment with Dex may be beneficial to reduce post-chemotherapy symptoms induced by irinotecan, specifically anorexia and fatigue, with acceptable toxicities.

ジャーナルSupportive Care in Cancer
出版ステータスPublished - 2003 8月 1

ASJC Scopus subject areas

  • 腫瘍学


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