Raman spectroscopic study on the conformation of a peptide fragment representing the DNA-binding domain of filamentous virus Pf3 coat protein

Takashi Miura, Hideo Takeuchi, Issei Harada

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Raman spectra have been measured of a nonapeptide which has an amino acid sequence identical to that of the C-terminal region of the major coat protein subunit of Filamentous bacteriophage Pf3. The peptide shows a strong tendency to form a β-sheet structure in aqueous solution. The β-sheet formation is significantly promoted by complexation with single-stranded DNA but not with double-stranded DNA. It is suggested that the C-terminal region of the Pf3 coat protein binds to the single-stranded DNA genome in the virion with a β-sheet conformation, in sharp contrast with the α-helical binding in other filamentous bacteriophages.

本文言語English
ページ(範囲)181-184
ページ数4
ジャーナルFEBS Letters
307
2
DOI
出版ステータスPublished - 1992 7 28

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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