Quantitative targeted proteomics for understanding the blood-brain barrier: Towards pharmacoproteomics

Sumio Ohtsuki, Mio Hirayama, Shingo Ito, Yasuo Uchida, Masanori Tachikawa, Tetsuya Terasaki

研究成果: Review article

27 引用 (Scopus)

抜粋

The blood-brain barrier (BBB) is formed by brain capillary endothelial cells linked together via complex tight junctions, and serves to prevent entry of drugs into the brain. Multiple transporters are expressed at the BBB, where they control exchange of materials between the circulating blood and brain interstitial fluid, thereby supporting and protecting the CNS. An understanding of the BBB is necessary for efficient development of CNS-acting drugs and to identify potential drug targets for treatment of CNS diseases. Quantitative targeted proteomics can provide detailed information on protein expression levels at the BBB. The present review highlights the latest applications of quantitative targeted proteomics in BBB research, specifically to evaluate species and in vivo-in vitro differences, and to reconstruct in vivo transport activity. Such a BBB quantitative proteomics approach can be considered as pharmacoproteomics.

元の言語English
ページ(範囲)303-313
ページ数11
ジャーナルExpert Review of Proteomics
11
発行部数3
DOI
出版物ステータスPublished - 2014 6

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

フィンガープリント Quantitative targeted proteomics for understanding the blood-brain barrier: Towards pharmacoproteomics' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用