Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with 11C-AC-5216

Michie Miyoshi, Hiroshi Ito, Ryosuke Arakawa, Hidehiko Takahashi, Harumasa Takano, Makoto Higuchi, Masaki Okumura, Tatsui Otsuka, Fumitoshi Kodaka, Mizuho Sekine, Takeshi Sasaki, Saori Fujie, Chie Seki, Jun Maeda, Ryuji Nakao, Ming Rong Zhang, Toshimitsu Fukumura, Masayasu Matsumoto, Tetsuya Suhara

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Peripheral benzodiazepine receptor (PBR) is upregulated in activated glial cells and is therefore a useful biomarker for inflammation in the brain and neurodegenerative disorders. We developed a new PET radioligand, 11C-AC-N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-pheyl-7, 8-dihydro-9H-purin-9-yl)acetamide (11C-AC-5216), that allows the imaging and quantification of PBRs in monkey and mouse brains. The aim of this study was to evaluate a quantification method of 11C-AC-5216 binding in the human brain. Methods: A 90-min dynamic PET scan was obtained for each of 12 healthy men after an intravenous injection of 11CAC-5216. Regions of interest were drawn on several brain regions. Binding potential, compared with nondisplaceable uptake (BPND), was calculated by a nonlinear least-squares fitting (NLS) method with the 2-tissue-compartment model, and total volume of distribution (VT) was estimated by NLS and graphical analysis methods. Results: BPND was highest in the thalamus (4.6 ± 1.0) and lowest in the striatum (3.5 ± 0.7). VT obtained by NLS or graphical analysis showed regional distribution similar to BPND. However, there was no correlation between BPND and VT because of the interindividual variation of K1/k2. BPND obtained with data from a scan time of 60 min was in good agreement with that from a scan time of 90 min (r = 0.87). Conclusion: Regional distribution of 11C-AC-5216 was in good agreement with previous PET studies of PBRs in the human brain. BPND is more appropriate for estimating 11C-AC- 5216 binding than is VT because of the interindividual variation of K 1/k2. 11C-AC-5216 is a promising PET ligand for quantifying PBR in the human brain.

本文言語English
ページ(範囲)1095-1101
ページ数7
ジャーナルJournal of Nuclear Medicine
50
7
DOI
出版ステータスPublished - 2009 7 1
外部発表はい

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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