Quantitative analysis of acetone in breath using vacuum-ultraviolet spectroscopy based on hollow-optical-fiber gas cell

Y. Kudo, Y. Matsuura

研究成果: Conference contribution

抄録

A vacuum-ultraviolet (VUV) spectroscopy system is proposed for measurement of acetone in human breath that has been attracting attention as a biomarker of body fat metabolism and diagnosis of diabetes. A strong absorption peak of acetone at 195 nm is detected by using a simple system consisting of a deuterium lamp source, a hollow-core fiber gas cell, and a fiber-coupled compact spectrometer corresponding the VUV region. The hollow-core fiber functions as a long path and extremely small volume gas cell and enables sensitive measurement of trace components in exhaled breath. For breath analysis, we applied multiple regression analysis using absorption spectra of O2, H2O, and the acetone standard gas as explanatory variables to quantitate the concentration of acetone in breath. We applied standard addition method based on human breath and as a result, it was found that the measurement accuracy was 0.074 ppm in standard deviation (SD) for healthy human breath with the acetone concentration of around 0.8 ppm and precision was 0.026 ppm SD. We also tried to monitor body fat burn based on breath acetone and confirmed that breath acetone increased after exercises because acetone is a volatile byproduct of lipolysis.

本文言語English
ホスト出版物のタイトルOptical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI
編集者Israel Gannot, Katy Roodenko
出版社SPIE
ISBN(電子版)9781510641051
DOI
出版ステータスPublished - 2021
イベントOptical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI 2021 - Virtual, Online, United States
継続期間: 2021 3 62021 3 11

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
11635
ISSN(印刷版)1605-7422

Conference

ConferenceOptical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI 2021
国/地域United States
CityVirtual, Online
Period21/3/621/3/11

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング

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