Putative gap junctional communication between axon and regenerating Schwann cells during mammalian peripheral nerve regeneration

M. Dezawa, T. Mutoh, A. Dezawa, E. Adachi-Usami

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Gap junctions are intercellular channels which mediate the traffic of ions and a variety of molecular messengers between contiguous cells. Here, we report on the possibility that atypical gap junctions develop between heterologous tissues, such as regenerating nerve axons and Schwann cells, during peripheral nerve regeneration in adult rats. After a complete transection and subsequent regeneration in the rat sciatic nerve distal segment, a small scale gap junction-like structure was observed between the regenerating axons and adjoining Schwann cells. Immunoelectron microscopy showed that one of the gap junctional proteins, connexin32, was located at a small region of contact between the axon and Schwann cells. Biocytin, a small molecular weight dye, was transported from regenerating axons into adjoining Schwann cells. The present findings suggest that regenerating axons communicate directly with adjacent Schwann cells through small gap junctions, which may play a role in the mechanism of regeneration following nerve transection.

本文言語English
ページ(範囲)663-667
ページ数5
ジャーナルNeuroscience
85
3
DOI
出版ステータスPublished - 1998 4月 24
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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