PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma

Kazunori Uegaki, Yasunobu Kanamori, Junzo Kigawa, Wakae Kawaguchi, Ruri Kaneko, Jun Naniwa, Masakuni Takahashi, Muneaki Shimada, Tetsuro Oishi, Hiroaki Itamochi, Naoki Terakawa

研究成果: Article査読

55 被引用数 (Scopus)

抄録

PTEN and the PI3K/Akt pathway are involved in the development and/or progression of endometrial carcinoma. To clarify the impact of the pathway-related molecules on prognosis, we analyzed PTEN, phosphorylated-Akt (p-Akt), and Ki-67 expression by immunohistochemistry in 99 patients with advanced endometrial carcinoma. PTEN-negative or PTEN-mixed staining was found in 66% of tumors. Positive staining of p-Akt was found in 40% of tumors. Loss of PTEN expression (negative or mixed) was significantly associated with positive p-Akt expression. The patients with PTEN-positive and p-Akt-negative expression clearly showed a higher survival rate than patients in the other groups. Subsequent multivariate analysis revealed that the combination of PTEN/Akt expression was an independent prognostic factor. Examining the relationship between p-Akt expression and Ki-67 labeling index (LI), we found that negative p-Akt was related to a decrease in Ki-67 LI. Additionally, the patients with low Ki-67 LI, as determined by p-Akt-expression status, had a better prognosis. In the present study, we demonstrated that PTEN-positive and p-Akt-negative expression was a predictor of survival for patients with advanced endometrial carcinoma. This study suggests the clinical significance of PTEN and p-Akt expression analysis in treatment decisions for patients with advanced endometrial carcinoma.

本文言語English
ページ(範囲)389-392
ページ数4
ジャーナルOncology reports
14
2
DOI
出版ステータスPublished - 2005 8
外部発表はい

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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